Crystal For Mac: A User-Friendly and Feature-Rich App to Analyze Your Hard Disk Performance

Group A Streptococcus secretes cysteine proteases named Mac-1 and Mac-2 that mediate host immune evasion by targeting both IgG and Fc receptors. Here, we report the crystal structures of Mac-1 and its catalytically inactive C94A mutant in two different crystal forms. Despite the lack of sequence homology, Mac-1 adopts the canonical papain fold. Alanine mutations at the active site confirmed the critical residues involved in a papain-like catalytic mechanism. Mac-1 forms a symmetric dimer in both crystal forms and displays the unique dimer interface among papain superfamily members. Mutations at the dimer interface resulted in a significant reduction in IgG binding and catalysis, suggesting that the dimer contributes to both IgG specificity and enzyme cooperativity. A tunnel observed at the dimer interface constitutes a target for designing potential Mac-1-specific antimicrobial agents. The structures also offer insight into the functional difference between Mac-1 and Mac-2.

I think I got it sorted with your suggestions. I had to brew unlink bdw-gc, then brew install libatomic_ops and then brew link bdw-gc --HEAD. Then copy the right libgc.a file into the crystal root. I updated the instructions in my linked gist. Still have to run specs, but it runs and reports a version

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Featuring an easy drag-and-drop workflow, our elegant interfaces maximize your productivity and empower you to "see the wood for the trees" and understand the nano-scale world: it's crystallography without the pain.LEARN MORE...

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The measurement of Mass Attenuation Coefficients is usually carried out using characteristic x-ray lines from x-ray tubes or an x-ray fluorescent sources. These techniques employ a single or double crystal spectrometer. However, some investigators use selected wavelengths from the Bremsstrahlung radiation. This latter technique has the problem of a lower peak-to-background ratio because of the coherent and incoherent scattered radiation by the crystal for the total Bremsstrahlung. In order to minimize the scattered radiation, a thick (5 mm) silicon Borrmann crystal was used. In order to obtain a suitable signal, a Rigaku rotating anode was used. Operating the x-ray tube at 20 keV and 200 ma, the intensity was measured in steps of 1 from 20 to 40 two-theta. This will cover the energy-range of 9.44 to 18.60 keV. This procedure was carried out with and without the foil. 2ff7e9595c